Diabetic muscle infarction and diabetic dermopathy two manifestations of uncontrolled prolong diabetes mellitus presenting with severe leg pain and leg skin lesions
© Shenavandeh et al.; licensee BioMed Central Ltd. 2014
Received: 12 January 2013
Accepted: 19 January 2014
Published: 21 February 2014
Diabetic muscular infarction (DMI) is a rare manifestation which can be seen in patients with long-standing diabetes mellitus. Patients usually come with painful swelling of an involved muscle in one extremity. MRI and biopsy histology can help diagnose this condition. Diabetic dermopathy is another manifestation of patients with diabetes.
We present a patient with uncontrolled diabetes type 2 presented with pain, swelling, and a palpable tender mass in one leg along with new skin lesions. Biopsy of the skin lesion and T2-weighted MRI of the leg helped differentiate DMI and dermopathy.
KeywordsDiabetic muscle infarct Diabetic dermopathy Leg pain
Diabetic muscular infarction (DMI) is a rare condition which has been seen in patients with long-standing diabetes who usually have other complications of poor glycemic control. It has been reported as aseptic myonecrosis, ischemic myonecrosis, and tumoriform focal muscular degeneration.
DMI was first described by Angervall and Stener in 1965 . It presents as an acute onset of painful swelling of the affected muscle. MRI and biopsy histology can help differentiate it with other similar conditions. Even though DMI has been reported for over 45 years, still, less than 200 cases have been reported .
We are presenting a rare manifestation of uncontrolled diabetes type 2 in a patient who came with pain, swelling, and a palpable tender mass in one leg along with new skin lesions.
A 57 year old woman, with uncontrolled diabetes type 2 and hypertension, referred to a university hospital clinic with a complaint of right leg swelling and tenderness since 40 days prior to admission. She didn’t give a history of trauma, bite, muscle weakness or fever. She had received analgesics (ibuprofen 400 mg bid and diclofenac 50 mg bid) and cephalexin without any improvement.
Our treatment strategy was to control her glucose level with NPH and regular insulin. We also gave her naproxen 500 mg bid with occasional morphine injections. She was advised to avoid weight-bearing. Aspirin, low dose heparin, gabapentine, alprazolam and imipramine were also given. After 2 weeks the patient had a moderate improvement in pain and was able to walk with a walker.
DMI is an uncommon complication of long-standing uncontrolled diabetes of both type 1 and 2 . The pathogenesis is not clear. The most likely hypothesis is vascular diseases like arteriosclerosis and diabetic microangiopathy . Thigh muscles are the most commonly affected and reports of lower leg involvement are very rare . Upper extremity involvement has also been reported .
Clinical features usually consist of local swelling, limitation and pain on motion, tenderness, and a palpable painful mass, usually without fever and severe induration. Muscle enzymes are usually not elevated and an elevated ESR was seen in about 50%.
Diagnosis can be made combining clinical presentation and radiologic imaging. MRI is one of the best methods. Electromyography has been shown to help in some cases . Biopsy confirms the diagnosis in over 90% of cases , but since it has potential complications, it should be reserved for atypical cases were diagnosis is hard to make. The main reason why biopsies are not performed regularly is that those who have biopsies also have a longer course of pain and associated problems.
The most common differential diagnoses are deep venous thrombosis and pyomyositis, although soft-tissue abscess, necrotizing fasciitis, dermatomyositis, proliferative myositis, focal myositis, nodular myositis, primary lymphoma of muscle, benign tumors or sarcomas of the muscle, diabetic amyotrophy, osteomyelitis, exertional muscle rupture, and ruptured Baker’s cyst were also noted [8, 9].
Diabetic dermopathy, sometimes termed pigmented pretibial papules, or “diabetic skin spots,” begins as an erythematous area and evolves into an area of circular hyperpigmentation that is in patients with long-standing diabetes and no treatment is warranted .
In our patient the presentation was localized muscle involvement and skin lesions in an uncontrolled diabetic patient, which DMI along with diabetic dermopathy had been diagnosed. This was the first report of DMI and diabetic dermopathy together. As the rate of diabetes mellitus is rising, we might be seeing these patients more often and we should be concerned about them. Treatment is controversial, but trials of anti-platelets, anticoagulation, analgesics, off-loading, rehabilitation methods, and anti-depressants have been used. We recommend more thorough clinical trials to see if these treatment regimens significantly improve the outcome.
In conclusion DMI is an uncommon complication of long-standing uncontrolled diabetes presenting with swelling and severe pain usually in lower extremity and usually prompts an extensive diagnostic workup to find etiology of localized myositis which might be unnecessary if the physician has a high level of suspicion, and a T2-weighted MRI images can be a good diagnostic help.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
- Iyer SN, Drake AJ, West RL, Tanenberg RJ: Diabetic Muscle Infarction: a rare complication of long-standing and poorly controlled diabetes mellitus. Case Rep Med 2011, 2011: 407921.PubMedPubMed Central
- Lafforgue P, Janand-Delenne B, Lassman-Vague V, Daumen-Legre V, Pham T, Vague P: Painful swelling of the thigh in a diabetic patient: diabetic muscle infarction. Diabetes Metab 1999, 25: 255–260.PubMed
- Scully RE, Mark EJ, McNelly WF, Ebeling SH, Phillips LD: Case 29: case records of the Massachusetts General Hospital. N Engl J Med 1997, 337: 839–845. 10.1056/NEJM199709183371208View Article
- Morcuende JA, Dobbs MB, Crawford H, Buckwalter JA: Diabetic muscle infarction. Iowa Orthop J 2000, 20: 65–74.PubMedPubMed Central
- Cardillo S, Huse JT, Iqbal N: Diabetic muscle infarctionof the forearm in a patient with long-standing type 1 diabetes. Endocr Pract 2006, 12: 188–192. 10.4158/EP.12.2.188View ArticlePubMed
- Anglada M, Vidaller A, Bolao F, Ferrer I, Olive’ M: Diabetic muscle infarction. Muscle Nerve 2000, 23: 825–826. 10.1002/(SICI)1097-4598(200005)23:5<825::AID-MUS25>3.0.CO;2-IView ArticlePubMed
- Chester CS, Banker BQ: Focal infarction of muscle in diabetics. Diabetes Care 1986, 9: 623–630. 10.2337/diacare.9.6.623View ArticlePubMed
- Jelinek JS, Murphey MD, Aboulafia AJ, Dussault RG, Kaplan PA, Snearly WN: Muscle infarction in patients with diabetes mellitus: MR imaging findings. Radiology 1999, 211: 241–247. 10.1148/radiology.211.1.r99ap44241View ArticlePubMed
- Rocca PV, Alloway JA, Nashel DJ: Diabetic muscular infarction. Semin Arthritis Rheum 1993, 22: 280–287. 10.1016/0049-0172(93)80076-RView ArticlePubMed
- Powers AC: Diabetes Mellitus. In Harrison’s Principles of Internal Medicine, Volume 2. 18th edition. Edited by: Longo D, Fauci A, Kasper D, Hauser S, Jameson J. New York: McGraw-Hill; 2012:2988.
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